Cause of Small Fiber Neuropathy

Small fiber neuropathies can be caused by disorders of metabolism such as diabetes, chronic infections (such as human immunodeficiency virus), genetic abnormalities, toxicity from various drugs, and autoimmune diseases. The cause, however, often remains a mystery. As more research has been developed over the past couple of years, it has become clear that Impaired Glucose Tolerance (IGT) is a frequent cause for small fiber neuropathies.